Probing structural changes in single enveloped virus particles using nano-infrared spectroscopic imaging.
Enveloped viruses, such as HIV, Ebola and Influenza, are among the most deadly known viruses.Cellular membrane penetration of enveloped viruses is a critical step in the cascade of events that lead to entry into the host cell.Conventional ensemble fusion assays rely on collective responses to membrane fusion events, and do not allow direct and quan